Irvingia supplement influences at least five key components of fat metabolism. The research details on the impact of Irvingia on weight loss may seem a little technical here. However, they show how unique this herb is in the number of ways that it directs weight loss. This list makes Irvingia unlike any other weight loss supplement. The key effects are as follows.
1) Adiponection is a hormone that is secreted by large fat cells to help support insulin sensitivity and cardiovascular health. Irvingia causes a significant increase in adiponectin levels in overweight people.
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2) Glycerol-3-phosphate dehydrogenase is an enzyme that converts glucose into triglycerides that then go into storage in fat cells. The result is to make fat cells fatter. Irvingia inhibits the activity of this enzyme, thereby slowing down the growth of fat cells.
3) C-reactive protein blocks the activity of leptin, the master fat hormone, which leads to leptin resistance. Leptin resistance causes fat gain. Overweight people taking Irvingia extract have lower levels of CRP, thereby restoring normal leptin activity and proper fat metabolism.
4) Amylase is an enzyme that breaks down starch to release glucose. Glucose is then absorbed in the digestive tract and taken up as blood sugar. Irvingia inhibits the action of amylase, thereby reducing the number of calories that can be absorbed from eating starch.
5) PPAR-gamma is a key enzyme that regulates the formation of new fat cells and insulin sensitivity. Irvingia inhibits the formation of new fat cells by it influence on PPAR-gamma.
Irvingia Research
The U.S. National Institutes of Health medical database (PubMed) lists 28 research articles that were published on Irvingia since 1980. They involve a wide range of studies on the role of Irvingia in reducing blood sugar in diabetics, relieving pain relief, preventing malaria, in treating bacterial and fungal infections, and even in making Irvingia wine. This variety of effects comes from more than one species of Irvingia and more than one plant part.
The research relevant to the development of this herb as a weight loss supplement concerns an extract of the seeds of one species, Irvingia gabonensis.
Clinical Research On Irvingia Gabonensis Seed Extract
Recent human studies on supplementation using the seed extract of Irvingia gabonensis show significant positive changes after 10 weeks in the following tests: total cholesterol, LDL cholesterol, blood glucose, C-reactive protein, adiponectin, and leptin. These results were based the twice-daily, 150 mg dose, of a proprietary Irvingia gabonensis seed extract.
In addition to the metabolic measurements above, the Irvingia-treated group in this study also lost an average of 12.8 kg (28 lbs) and 6.3 percent body fat. Furthermore, mean waist size in the treatment group dropped just over 16 cm (more than 6 inches) during the study period.
This and other studies shows a remarkably diverse set of physiological effects from Irvingia. Other studies also show its effects on regulating genes that influence the production of hormones and enzymes that control fat metabolism.
Irvingia Side Effects
The main side effect in research studies, and from individual testimonies by people who take Irvingia, is a decrease in appetite. This probably has to do with how the herb reinvigorates leptin activity. Poor leptin activity is associated with hunger and a greater appetite.
Irvingia is also less effective if people eat too much. In other words, it is not a license to overeat.
This herb also seems to have different effects on people who eat a low carb diet. Since the actions of Irvingia are directed at carbohydrate metabolism as it relates to fat cells, complex carbs seem to be important when using this supplement.
Researchers in Cameroon, where Irvingia is a native food source, noticed that long-term consumption of the seeds of this plant is associated with two main side effects:
1) resistance to diabetes; and,
2) resistance to obesity.
These observations are what attracted the attention of medical researchers in the first place. Seeds of Irvingia have been used by indigenous populations as a soup thickener for centuries. People have not suffered any apparent negative side effects from Irvingia even though they typically eat it almost every day of their lives.
Irvingia Extract Weight Loss and Side Effects
Dr. Dennis Clark is a retired university professor and research scientist, specializing in natural products biochemistry and human health. His scientific analysis of belly fat science is full of pleasant and unpleasant surprises for those who want to lose belly fat. Get his free scientific report (5 Steps to a Slimmer and Healthier You) on the most important ways to get slimmer permanently, at http://bellyfatscience.com/.